Difference between revisions of Clinical Studies

(38 intermediate revisions by 4 users not shown)

Line 57:

*[https://pubmed.ncbi.nlm.nih.gov/3631199/''"This experiment shows the effectiveness of automated accommodative training (active focus) in reducing asthenopia (eye strain) and improving accommodative facility."'' AmJOPO, 1987]

==~~References~~==

==LASIK==

~~{{reflist}}~~

A good resource for information about [[LASIK]]: [https://lasikcomplications.com/ lasikcomplications.com]

* [https://journals.sagepub.com/doi/abs/10.5301/ejo.5000025 Less than 20% of people with 10+ diopters will be below 1 diopter just 3 years after LASIK]

==Articles==

===From the blog===

These are blog articles on EndMyopia about clinical studies, but not clinical studies themselves. You may find them interesting. Also see [https://endmyopia.org/category/science/ the science category].

*[https://endmyopia.org/dr-morgan-dr-megaw-preventing-axial-elongation-and-the-development-of-myopia/ what we know about axial elongation of the eye, and its role in the development of myopia (dissertation)]

*[https://endmyopia.org/your-eyes-are-direct-access-to-your-brain-blue-light-reverses-amnesia/ in some cases, memories that are lost due to brain trauma may still be present in the human brain. (animal testing)]

*[https://endmyopia.org/shots-in-the-dark-clinical-myopia-studies/ studies that have considered the negative impact of minus lens use for close-up, and looked into smarter alternatives to “minus for everything”.]

*[https://endmyopia.org/the-role-of-contrast-adaptation-in-myopia-development-reversal/ The Role Of Contrast Adaptation In Myopia Development & Reversal]

*[https://endmyopia.org/no-more-surgery-a-new-eye-drop-dissolves-cataracts/ Researchers in the US have developed a new drug that can be delivered directly into the eye via an eye dropper to shrink down and dissolve cataracts – the leading cause of blindness in humans. (animal testing) (2015)]

*[https://endmyopia.org/the-1960s-harvard-pirate-kitten-experiment-an-unused-eye-goes-blind/ Back in the 1960’s this guy Torsten Wiesel from the Harvard Medical School’s department of neurobiology ran an experiment on kittens. (animal testing)]

*[https://endmyopia.org/forget-thick-contacts-get-thinner-contact-lenses/ On contact lenses]

*[https://endmyopia.org/sugar-risk-diabetic-retinopathy/ Diabetic retinopathy. Or, how your eating habits can take you straight into one of the leading causes of adult blindness.]

*[https://endmyopia.org/glasses-make-your-eyes-grow-not-in-a-good-way/ wearing glasses to correct myopia, will create more myopia.]

*[https://endmyopia.org/steroids-to-boost-dynamic-visual-acuity/ Dynamic Visual Acuity]

*[https://endmyopia.org/night-blindness-seeing-well-bright-vs-dim-light/ Night blindness]

*[https://endmyopia.org/us-national-academy-of-sciences-near-work-causes-myopia/ Near Work Causes Myopia (USNAS)]

*[https://endmyopia.org/lens-induced-myopia-investigative-ophthalmology/ Lens-Induced Myopia]

*[https://endmyopia.org/can-axial-length-be-reduced-for-less-myopia/ Can Axial Length Be Reduced For Less Myopia?]

*[https://endmyopia.org/bi-focal-contact-lenses-for-myopia-control/ Bi-Focal Contact Lenses For Myopia Control]

*[https://endmyopia.org/monkey-see-monkey-do/ Negative lens-induced myopia in infant monkeys: effects of high ambient lighting (animal study)]

*[https://endmyopia.org/breaking-science-discovers-the-cause-of-nearsightedness/ Myopia starts with environmental stimulus, in particular extended close-up focus.]

*[https://endmyopia.org/eye-drop-warning-avoid-benzalkonium-chloride/ Eye Drop Warning: Avoid Benzalkonium Chloride]

*[https://endmyopia.org/the-hong-kong-myopia-epidemic/ The Hong Kong Myopia Epidemic]

*[https://endmyopia.org/the-unstoppable-global-myopia-epidemic-doubles-again/ incidence of childhood myopia among American children has more than doubled over the last 50 years]

*[https://endmyopia.org/glasses-cause-serious-psychological-stress-in-children/ Psychological Stress in Childhood and Myopia Development (OVPJournal)]

*[https://endmyopia.org/cruel-cruel-winter/ Unless you find uncle Jake’s myopia rehab facility, you’re in the lens manufacturer’s drug dealing pocket for life.] (no paper)

*[https://endmyopia.org/improved-glaucoma-detection-singapore-study/ you can reduce your risk of the most common forms of glaucoma]

*[https://endmyopia.org/eyes-in-various-species-can-shorten-to-compensate-for-myopic-defocus/ Eyes in Various Species Can Shorten to Compensate for Myopic Defocus] and [https://endmyopia.org/three-mammals-and-a-bird/ commentary by contributing optometrist] (animal studies)

*[https://endmyopia.org/study-bifocal-contact-lenses-for-myopia-control/ Bifocal contacts control myopia progression better than multifocal spectacles]

*[https://endmyopia.org/geeks-retina-its-own-sensorimotor-apparatus/ A Sensorimotor Account Of Vision And Visual Consciousness (philosophy paper)]

*[https://endmyopia.org/contrast-sensitivity/ contrast sensitivity (no paper)]

*[https://endmyopia.org/is-going-outside-the-cure-for-myopia/ why outdoor time won’t magically prevent myopia onset]

*[https://endmyopia.org/singapore-ophthalmologist-insists-glasses-dont-cause-myopia/ glasses cause more myopia, faster]

*https://endmyopia.org/peripheral-vision-loss/

*https://endmyopia.org/allan-hytowitz-genius-innovator-or-dangerous-heretic/

*https://endmyopia.org/this-woman-sees-99-million-more-colors-than-you/

*https://endmyopia.org/neural-response-to-flicker-rates-artificial-light-causes-myopia/

*https://endmyopia.org/ophthalmology-science-glasses-cause-myopia-period/

*https://endmyopia.org/coopervision-misight-contact-lenses-breakthrough-myopia-control/

*https://endmyopia.org/myopia-madness-glasses-way-strong/

*https://endmyopia.org/retail-optometry-even-science/

*https://endmyopia.org/eye-uses-chromatic-aberration-to-guide-axial-change/

*https://endmyopia.org/american-journal-of-optometry-adult-reduction-in-axial-length/

*https://endmyopia.org/studies-does-undercorrection-cause-more-myopia/

*https://endmyopia.org/science-confirms-human-eye-axial-length-change-lens-use/

*https://endmyopia.org/another-study-glasses-cause-rapid-myopia-progression-in-children/

*https://endmyopia.org/active-focus-does-it-actually-work-clinical-science/

*https://endmyopia.org/refractive-error-myopia-concept/

*https://endmyopia.org/shocking-news-not-all-ophthalmologists-are-retarded/

*https://endmyopia.org/optics-diopters-all-the-nerdy-maths/

*https://endmyopia.org/astigmatism-part-of-natural-focus-understanding-the-brains-autofocus-mechanism/

*https://endmyopia.org/can-this-tiny-piece-of-paper-replace-your-optometrist/

*https://endmyopia.org/why-is-my-eyesight-worse-in-low-light-indoors-dusk-night-time/

*https://endmyopia.org/study-outdoor-activity-reduces-myopia-onset-in-children/

*https://endmyopia.org/study-failure-to-discuss-myopia-control-verging-on-negligent/

*https://endmyopia.org/why-you-are-nearsighted-an-animation/

===From the forum===

Here are papers people have mentioned on the forum:

* [https://www.visionsofjoy.org/pdfs/OrfieldSeeingSpace.pdf Seeing Space: Undergoing Brain Reprogramming to Reduce Myopia] by Antonia Marie Orfield (1994); [https://www.legacy.com/us/obituaries/bostonglobe/name/antonia-orfield-obituary?id=24225499 Author's obituary]

*[https://community.endmyopia.org/t/showdown-experiment-will-enough-outdoor-vision-shorten-my-eyes/6423/200 a paper which tries to model how the human (and generally mammalian) eyes focus on objects (animal study)] [https://www.sciencemag.org/news/2011/10/deciphering-brains-autofocus-mechanism (short article)], [https://www.pnas.org/content/108/40/16849 (full paper)]

*[https://community.endmyopia.org/t/been-to-the-opto-but-with-unexpecting-results-glaucoma/5203/5 a proto-endmyopia thing] [https://the-eye.eu/public/concen.org/Five_Health_Classics/BENJAMIN%2C%20Harry%20-%20Better%20Sight%20Without%20Glasses%20%281962%29.pdf (here is the direct link to an old book, start with page 102.)]

*[https://community.endmyopia.org/t/been-to-the-opto-but-with-unexpecting-results-glaucoma/5203/19 If you have glaucoma, try vitamin b3] (Clin & Exp Ophtalm. Sept. 2020, doi: 10.1111/ceo.13818)

*[https://community.endmyopia.org/t/my-journey-from-4-25-halmadavid/5080/245 Probability of myopia in children with high refined carbohydrates consumption in France] [https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01602-x (direct link to research article)]

*[https://community.endmyopia.org/t/doubts-about-the-need-for-outdoors-and-avoiding-screen-time/8940/18 on the effects of outdoor light on myopia progression] [https://www.nature.com/articles/519276a (direct link to article)]

* [http://www.myopia.org/bifocals.htm Bifocal Control of Myopia study by Oakley and Young, 1975.]

*[https://community.endmyopia.org/uploads/short-url/2WB7z5dmF3Rk7tdwlslsf9zcwh0.pdf Visual Conditions of Symphony Musicians]

* a bunch at [https://community.endmyopia.org/t/better-than-eye-chart/15290/11 Better than eye chart?] [https://www.dyop.info/documents/Measuring_Visual_Cylinder_and_Axis_with_a_Dyop.pdf (pdf)], [https://www.bitchute.com/video/yPeGRG4qWQsi/ (visual acuity testing demo)], [https://www.dyop.info/documents/How_We_See.pdf (how we see pdf)], [https://www.dyop.info/documents/Snellen_vs_Dyop-Cataracts_Gordon.pdf (pdf)], [https://www.dyop.info/documents/Snellen_vs_Dyop_Refractions-Sanni.pdf (pdf)], [https://www.dyop.info/documents/Dyslexia_and_Color_Perception-SandraStark.pdf (pdf)], [https://www.dyop.info/documents/Which_Optotype_Are_You_Using.pdf (pdf)], etc. Discussion is about a proprietary tool that works better than the Snellen chart.

* [https://www.ncbi.nlm.nih.gov/books/NBK580526/#!po=11.1765 Pigment Dispersion Syndrome]

===From Discord or the wiki===

* [https://ia803109.us.archive.org/32/items/BETTERSIGHTWITHOUTGLASSESHarryBenjamin/BETTER%20SIGHT%20WITHOUT%20GLASSES%20harry%20benjamin.pdf Better sight without glasses by Dr. Harry Benjamin] (pdf) (related to [[Bates Method]], first published 1929)

[[Category:Articles]]

* a [https://github.com/kevindirect/papers-medbio/tree/master/conditions/opthamology/vision/myopia/papers collection of papers] on accommodation, defocus, lifestyle, miscellaneous, and myopia

==Documented case registry (EndMyopia)==

EndMyopia maintains a public, openly-licensed registry of adult myopia-reduction cases, deposited as a citable dataset and analysed in a preprint:

*Steiner, J. (2026). ''EndMyopia case registry: 273 adult cases'' [Dataset]. Zenodo. [https://doi.org/10.5281/zenodo.21016340 doi:10.5281/zenodo.21016340] (CC-BY-4.0)

*Steiner, J. (2026). ''A self-reported registry of adult myopia reduction: 273 documented cases (2013–2026)'' [Preprint]. Zenodo. [https://doi.org/10.5281/zenodo.21230819 doi:10.5281/zenodo.21230819]

The dataset is machine-readable and source-linked; median recorded reduction was −2.00 D, with 42 of 273 cases carrying third-party-exam or official-record corroboration. The data are self-reported and not a clinical trial.

@@ Line 57: / Line 57: @@
 *[https://pubmed.ncbi.nlm.nih.gov/3631199/''"This experiment shows the effectiveness of automated accommodative training (active focus) in reducing asthenopia (eye strain) and improving accommodative facility."'' AmJOPO, 1987]
-==References==
+==LASIK==
-{{reflist}}
+A good resource for information about [[LASIK]]: [https://lasikcomplications.com/ lasikcomplications.com]
+* [https://journals.sagepub.com/doi/abs/10.5301/ejo.5000025 Less than 20% of people with 10+ diopters will be below 1 diopter just 3 years after LASIK]
+==Articles==
+===From the blog===
+These are blog articles on EndMyopia about clinical studies, but not clinical studies themselves. You may find them interesting. Also see [https://endmyopia.org/category/science/ the science category].
+*[https://endmyopia.org/dr-morgan-dr-megaw-preventing-axial-elongation-and-the-development-of-myopia/ what we know about axial elongation of the eye, and its role in the development of myopia (dissertation)]
+*[https://endmyopia.org/your-eyes-are-direct-access-to-your-brain-blue-light-reverses-amnesia/  in some cases, memories that are lost due to brain trauma may still be present in the human brain. (animal testing)]
+*[https://endmyopia.org/shots-in-the-dark-clinical-myopia-studies/ studies that have considered the negative impact of minus lens use for close-up, and looked into smarter alternatives to “minus for everything”.]
+*[https://endmyopia.org/the-role-of-contrast-adaptation-in-myopia-development-reversal/ The Role Of Contrast Adaptation In Myopia Development & Reversal]
+*[https://endmyopia.org/no-more-surgery-a-new-eye-drop-dissolves-cataracts/ Researchers in the US have developed a new drug that can be delivered directly into the eye via an eye dropper to shrink down and dissolve cataracts – the leading cause of blindness in humans. (animal testing) (2015)]
+*[https://endmyopia.org/the-1960s-harvard-pirate-kitten-experiment-an-unused-eye-goes-blind/ Back in the 1960’s  this guy Torsten Wiesel from the Harvard Medical School’s department of neurobiology ran an experiment on kittens. (animal testing)]
+*[https://endmyopia.org/forget-thick-contacts-get-thinner-contact-lenses/  On contact lenses]
+*[https://endmyopia.org/sugar-risk-diabetic-retinopathy/ Diabetic retinopathy.  Or, how your eating habits can take you straight into one of the leading causes of adult blindness.]
+*[https://endmyopia.org/glasses-make-your-eyes-grow-not-in-a-good-way/ wearing glasses to correct myopia, will create more myopia.]
+*[https://endmyopia.org/steroids-to-boost-dynamic-visual-acuity/ Dynamic Visual Acuity]
+*[https://endmyopia.org/night-blindness-seeing-well-bright-vs-dim-light/ Night blindness]
+*[https://endmyopia.org/us-national-academy-of-sciences-near-work-causes-myopia/ Near Work Causes Myopia (USNAS)]
+*[https://endmyopia.org/lens-induced-myopia-investigative-ophthalmology/ Lens-Induced Myopia]
+*[https://endmyopia.org/can-axial-length-be-reduced-for-less-myopia/ Can Axial Length Be Reduced For Less Myopia?]
+*[https://endmyopia.org/bi-focal-contact-lenses-for-myopia-control/ Bi-Focal Contact Lenses For Myopia Control]
+*[https://endmyopia.org/monkey-see-monkey-do/ Negative lens-induced myopia in infant monkeys: effects of high ambient lighting (animal study)]
+*[https://endmyopia.org/breaking-science-discovers-the-cause-of-nearsightedness/ Myopia starts with environmental stimulus, in particular extended close-up focus.]
+*[https://endmyopia.org/eye-drop-warning-avoid-benzalkonium-chloride/ Eye Drop Warning: Avoid Benzalkonium Chloride]
+*[https://endmyopia.org/the-hong-kong-myopia-epidemic/ The Hong Kong Myopia Epidemic]
+*[https://endmyopia.org/the-unstoppable-global-myopia-epidemic-doubles-again/ incidence of childhood myopia among American children has more than doubled over the last 50 years]
+*[https://endmyopia.org/glasses-cause-serious-psychological-stress-in-children/ Psychological Stress in Childhood and Myopia Development  (OVPJournal)]
+*[https://endmyopia.org/cruel-cruel-winter/  Unless you find uncle Jake’s myopia rehab facility, you’re in the lens manufacturer’s drug dealing pocket for life.] (no paper)
+*[https://endmyopia.org/improved-glaucoma-detection-singapore-study/ you can reduce your risk of the most common forms of glaucoma]
+*[https://endmyopia.org/eyes-in-various-species-can-shorten-to-compensate-for-myopic-defocus/ Eyes in Various Species Can Shorten to Compensate for Myopic Defocus] and [https://endmyopia.org/three-mammals-and-a-bird/ commentary by contributing optometrist] (animal studies)
+*[https://endmyopia.org/study-bifocal-contact-lenses-for-myopia-control/ Bifocal contacts control myopia progression better than multifocal spectacles]
+*[https://endmyopia.org/geeks-retina-its-own-sensorimotor-apparatus/ A Sensorimotor Account Of Vision And Visual Consciousness (philosophy paper)]
+*[https://endmyopia.org/contrast-sensitivity/ contrast sensitivity (no paper)]
+*[https://endmyopia.org/is-going-outside-the-cure-for-myopia/  why outdoor time won’t magically prevent myopia onset]
+*[https://endmyopia.org/singapore-ophthalmologist-insists-glasses-dont-cause-myopia/ glasses cause more myopia, faster]
+*https://endmyopia.org/peripheral-vision-loss/
+*https://endmyopia.org/allan-hytowitz-genius-innovator-or-dangerous-heretic/
+*https://endmyopia.org/this-woman-sees-99-million-more-colors-than-you/
+*https://endmyopia.org/neural-response-to-flicker-rates-artificial-light-causes-myopia/
+*https://endmyopia.org/ophthalmology-science-glasses-cause-myopia-period/
+*https://endmyopia.org/coopervision-misight-contact-lenses-breakthrough-myopia-control/
+*https://endmyopia.org/myopia-madness-glasses-way-strong/
+*https://endmyopia.org/retail-optometry-even-science/
+*https://endmyopia.org/eye-uses-chromatic-aberration-to-guide-axial-change/
+*https://endmyopia.org/american-journal-of-optometry-adult-reduction-in-axial-length/
+*https://endmyopia.org/studies-does-undercorrection-cause-more-myopia/
+*https://endmyopia.org/science-confirms-human-eye-axial-length-change-lens-use/
+*https://endmyopia.org/another-study-glasses-cause-rapid-myopia-progression-in-children/
+*https://endmyopia.org/active-focus-does-it-actually-work-clinical-science/
+*https://endmyopia.org/refractive-error-myopia-concept/
+*https://endmyopia.org/shocking-news-not-all-ophthalmologists-are-retarded/
+*https://endmyopia.org/optics-diopters-all-the-nerdy-maths/
+*https://endmyopia.org/astigmatism-part-of-natural-focus-understanding-the-brains-autofocus-mechanism/
+*https://endmyopia.org/can-this-tiny-piece-of-paper-replace-your-optometrist/
+*https://endmyopia.org/why-is-my-eyesight-worse-in-low-light-indoors-dusk-night-time/
+*https://endmyopia.org/study-outdoor-activity-reduces-myopia-onset-in-children/
+*https://endmyopia.org/study-failure-to-discuss-myopia-control-verging-on-negligent/
+*https://endmyopia.org/why-you-are-nearsighted-an-animation/
+===From the forum===
+Here are papers people have mentioned on the forum:
+* [https://www.visionsofjoy.org/pdfs/OrfieldSeeingSpace.pdf Seeing Space: Undergoing Brain Reprogramming to Reduce Myopia] by Antonia Marie Orfield (1994); [https://www.legacy.com/us/obituaries/bostonglobe/name/antonia-orfield-obituary?id=24225499 Author's obituary]
+*[https://community.endmyopia.org/t/showdown-experiment-will-enough-outdoor-vision-shorten-my-eyes/6423/200 a paper which tries to model how the human (and generally mammalian) eyes focus on objects (animal study)] [https://www.sciencemag.org/news/2011/10/deciphering-brains-autofocus-mechanism (short article)], [https://www.pnas.org/content/108/40/16849 (full paper)]
+*[https://community.endmyopia.org/t/been-to-the-opto-but-with-unexpecting-results-glaucoma/5203/5 a proto-endmyopia thing] [https://the-eye.eu/public/concen.org/Five_Health_Classics/BENJAMIN%2C%20Harry%20-%20Better%20Sight%20Without%20Glasses%20%281962%29.pdf (here is the direct link to an old book, start with page 102.)]
+*[https://community.endmyopia.org/t/been-to-the-opto-but-with-unexpecting-results-glaucoma/5203/19 If you have glaucoma, try vitamin b3] (Clin & Exp Ophtalm. Sept. 2020, doi: 10.1111/ceo.13818)
+*[https://community.endmyopia.org/t/my-journey-from-4-25-halmadavid/5080/245 Probability of myopia in children with high refined carbohydrates consumption in France] [https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01602-x (direct link to research article)]
+*[https://community.endmyopia.org/t/doubts-about-the-need-for-outdoors-and-avoiding-screen-time/8940/18 on the effects of outdoor light on myopia progression] [https://www.nature.com/articles/519276a (direct link to article)]
+* [http://www.myopia.org/bifocals.htm Bifocal Control of Myopia study by Oakley and Young, 1975.]
+*[https://community.endmyopia.org/uploads/short-url/2WB7z5dmF3Rk7tdwlslsf9zcwh0.pdf Visual Conditions of Symphony Musicians]
+* a bunch  at [https://community.endmyopia.org/t/better-than-eye-chart/15290/11 Better than eye chart?] [https://www.dyop.info/documents/Measuring_Visual_Cylinder_and_Axis_with_a_Dyop.pdf (pdf)], [https://www.bitchute.com/video/yPeGRG4qWQsi/ (visual acuity testing demo)], [https://www.dyop.info/documents/How_We_See.pdf (how we see pdf)], [https://www.dyop.info/documents/Snellen_vs_Dyop-Cataracts_Gordon.pdf (pdf)], [https://www.dyop.info/documents/Snellen_vs_Dyop_Refractions-Sanni.pdf (pdf)], [https://www.dyop.info/documents/Dyslexia_and_Color_Perception-SandraStark.pdf (pdf)], [https://www.dyop.info/documents/Which_Optotype_Are_You_Using.pdf (pdf)], etc.  Discussion is about a proprietary tool that works better than the Snellen chart.
+*  [https://www.ncbi.nlm.nih.gov/books/NBK580526/#!po=11.1765 Pigment Dispersion Syndrome]
+===From Discord or the wiki===
+* [https://ia803109.us.archive.org/32/items/BETTERSIGHTWITHOUTGLASSESHarryBenjamin/BETTER%20SIGHT%20WITHOUT%20GLASSES%20harry%20benjamin.pdf Better sight without glasses by Dr. Harry Benjamin] (pdf) (related to [[Bates Method]], first published 1929)
 [[Category:Articles]]
+* a [https://github.com/kevindirect/papers-medbio/tree/master/conditions/opthamology/vision/myopia/papers collection of papers] on accommodation, defocus, lifestyle, miscellaneous, and myopia
+==Documented case registry (EndMyopia)==
+EndMyopia maintains a public, openly-licensed registry of adult myopia-reduction cases, deposited as a citable dataset and analysed in a preprint:
+*Steiner, J. (2026). ''EndMyopia case registry: 273 adult cases'' [Dataset]. Zenodo. [https://doi.org/10.5281/zenodo.21016340 doi:10.5281/zenodo.21016340] (CC-BY-4.0)
+*Steiner, J. (2026). ''A self-reported registry of adult myopia reduction: 273 documented cases (2013–2026)'' [Preprint]. Zenodo. [https://doi.org/10.5281/zenodo.21230819 doi:10.5281/zenodo.21230819]
+The dataset is machine-readable and source-linked; median recorded reduction was −2.00 D, with 42 of 273 cases carrying third-party-exam or official-record corroboration. The data are self-reported and not a clinical trial.