Equalizing is improving one eye instead of both eyes at the same time. It's done to reduce the diopter gap between two eyes, so that both eyes have a more similar or identical level of correction. It is recommended to do at least 2 spherical reductions before attempting to equalize. At which point you will alternate a monocular (one eye only) drop, with a binocular (both eyes) drop or better still, two binocular drops before another monocular drop. It is not recommended to do two monocular drops in a row. This approach should work for spherical and cylindrical reductions alike, and like all reductions should be done in the standard of .25 at a time; except sometimes it is possible to reduce cylinder more by using spherical equivalent.
You will likely need to incorporate some patching through this process.