Difference between revisions of Clinical Studies

Add EndMyopia case-registry dataset + preprint citations (open data)
 
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{{under construction}}
Below you can find many third party clinical studies on the progression of myopia and how myopia may be reversed.
This article isn't fully developed, there are many studies that could go on this page that aren't here at the moment.
 
==Causes of Myopia==
==Causes of Myopia==
===Lens induced myopia (LIM) & axial length change in humans===
===Lens induced myopia (LIM) & axial length change in humans===
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===Using reduced or no lenses (myopic defocus)===
===Using reduced or no lenses (myopic defocus)===
*[https://www.nature.com/articles/s41598-020-65151-5''"The human eye is capable of responding to the presence of blur by changing its axial length, so that the retina moves towards the defocused image plane (using reduced lenses)...These findings provide evidence that the human eye is able to detect and respond to the presence (using reduced lenses)... of blur within minutes."'' Scientific Reports, 2020]
*[https://endmyopia.org/another-study-glasses-cause-rapid-myopia-progression-in-children/''"Our findings suggest that myopic defocus (using reduced lenses) slows the progression of myopia in already myopic children, supporting previous findings from animal studies..."'' IOVS, 2004]
*[https://endmyopia.org/another-study-glasses-cause-rapid-myopia-progression-in-children/''"Our findings suggest that myopic defocus (using reduced lenses) slows the progression of myopia in already myopic children, supporting previous findings from animal studies..."'' IOVS, 2004]
*[https://onlinelibrary.wiley.com/doi/full/10.1111/j.1475-1313.2008.00608.x''"Compared with SV lenses (Normal Glasses), myopia progression was found to be retarded by PALs (Bifocals / Reduced Lenses) to some extent in Chinese children"'' OPO, 2008]
*[https://onlinelibrary.wiley.com/doi/full/10.1111/j.1475-1313.2008.00608.x''"Compared with SV lenses (Normal Glasses), myopia progression was found to be retarded by PALs (Bifocals / Reduced Lenses) to some extent in Chinese children"'' OPO, 2008]
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*[https://pubmed.ncbi.nlm.nih.gov/3631199/''"This experiment shows the effectiveness of automated accommodative training (active focus) in reducing asthenopia (eye strain) and improving accommodative facility."'' AmJOPO, 1987]
*[https://pubmed.ncbi.nlm.nih.gov/3631199/''"This experiment shows the effectiveness of automated accommodative training (active focus) in reducing asthenopia (eye strain) and improving accommodative facility."'' AmJOPO, 1987]


==References==
==LASIK==
{{reflist}}
A good resource for information about [[LASIK]]: [https://lasikcomplications.com/ lasikcomplications.com]
* [https://journals.sagepub.com/doi/abs/10.5301/ejo.5000025 Less than 20% of people with 10+ diopters will be below 1 diopter just 3 years after LASIK]
 
==Articles==
 
===From the blog===
These are blog articles on EndMyopia about clinical studies, but not clinical studies themselves. You may find them interesting. Also see [https://endmyopia.org/category/science/ the science category].
 
*[https://endmyopia.org/dr-morgan-dr-megaw-preventing-axial-elongation-and-the-development-of-myopia/ what we know about axial elongation of the eye, and its role in the development of myopia (dissertation)]
*[https://endmyopia.org/your-eyes-are-direct-access-to-your-brain-blue-light-reverses-amnesia/  in some cases, memories that are lost due to brain trauma may still be present in the human brain. (animal testing)]
*[https://endmyopia.org/shots-in-the-dark-clinical-myopia-studies/ studies that have considered the negative impact of minus lens use for close-up, and looked into smarter alternatives to “minus for everything”.]
*[https://endmyopia.org/the-role-of-contrast-adaptation-in-myopia-development-reversal/ The Role Of Contrast Adaptation In Myopia Development & Reversal]
*[https://endmyopia.org/no-more-surgery-a-new-eye-drop-dissolves-cataracts/ Researchers in the US have developed a new drug that can be delivered directly into the eye via an eye dropper to shrink down and dissolve cataracts – the leading cause of blindness in humans. (animal testing) (2015)]
*[https://endmyopia.org/the-1960s-harvard-pirate-kitten-experiment-an-unused-eye-goes-blind/ Back in the 1960’s  this guy Torsten Wiesel from the Harvard Medical School’s department of neurobiology ran an experiment on kittens. (animal testing)]
*[https://endmyopia.org/forget-thick-contacts-get-thinner-contact-lenses/  On contact lenses]
*[https://endmyopia.org/sugar-risk-diabetic-retinopathy/ Diabetic retinopathy.  Or, how your eating habits can take you straight into one of the leading causes of adult blindness.]
*[https://endmyopia.org/glasses-make-your-eyes-grow-not-in-a-good-way/ wearing glasses to correct myopia, will create more myopia.]
*[https://endmyopia.org/steroids-to-boost-dynamic-visual-acuity/ Dynamic Visual Acuity]
*[https://endmyopia.org/night-blindness-seeing-well-bright-vs-dim-light/ Night blindness]
*[https://endmyopia.org/us-national-academy-of-sciences-near-work-causes-myopia/ Near Work Causes Myopia (USNAS)]
*[https://endmyopia.org/lens-induced-myopia-investigative-ophthalmology/ Lens-Induced Myopia]
*[https://endmyopia.org/can-axial-length-be-reduced-for-less-myopia/ Can Axial Length Be Reduced For Less Myopia?]
*[https://endmyopia.org/bi-focal-contact-lenses-for-myopia-control/ Bi-Focal Contact Lenses For Myopia Control]
*[https://endmyopia.org/monkey-see-monkey-do/ Negative lens-induced myopia in infant monkeys: effects of high ambient lighting (animal study)]
*[https://endmyopia.org/breaking-science-discovers-the-cause-of-nearsightedness/ Myopia starts with environmental stimulus, in particular extended close-up focus.]
*[https://endmyopia.org/eye-drop-warning-avoid-benzalkonium-chloride/ Eye Drop Warning: Avoid Benzalkonium Chloride]
 
*[https://endmyopia.org/the-hong-kong-myopia-epidemic/ The Hong Kong Myopia Epidemic]
*[https://endmyopia.org/the-unstoppable-global-myopia-epidemic-doubles-again/ incidence of childhood myopia among American children has more than doubled over the last 50 years]
*[https://endmyopia.org/glasses-cause-serious-psychological-stress-in-children/ Psychological Stress in Childhood and Myopia Development  (OVPJournal)]
*[https://endmyopia.org/cruel-cruel-winter/  Unless you find uncle Jake’s myopia rehab facility, you’re in the lens manufacturer’s drug dealing pocket for life.] (no paper)
*[https://endmyopia.org/improved-glaucoma-detection-singapore-study/ you can reduce your risk of the most common forms of glaucoma]
*[https://endmyopia.org/eyes-in-various-species-can-shorten-to-compensate-for-myopic-defocus/ Eyes in Various Species Can Shorten to Compensate for Myopic Defocus] and [https://endmyopia.org/three-mammals-and-a-bird/ commentary by contributing optometrist] (animal studies)
*[https://endmyopia.org/study-bifocal-contact-lenses-for-myopia-control/ Bifocal contacts control myopia progression better than multifocal spectacles]
*[https://endmyopia.org/geeks-retina-its-own-sensorimotor-apparatus/ A Sensorimotor Account Of Vision And Visual Consciousness (philosophy paper)]
*[https://endmyopia.org/contrast-sensitivity/ contrast sensitivity (no paper)]
*[https://endmyopia.org/is-going-outside-the-cure-for-myopia/  why outdoor time won’t magically prevent myopia onset]
*[https://endmyopia.org/singapore-ophthalmologist-insists-glasses-dont-cause-myopia/ glasses cause more myopia, faster]
*https://endmyopia.org/peripheral-vision-loss/
*https://endmyopia.org/allan-hytowitz-genius-innovator-or-dangerous-heretic/
*https://endmyopia.org/this-woman-sees-99-million-more-colors-than-you/
*https://endmyopia.org/neural-response-to-flicker-rates-artificial-light-causes-myopia/
*https://endmyopia.org/ophthalmology-science-glasses-cause-myopia-period/
*https://endmyopia.org/coopervision-misight-contact-lenses-breakthrough-myopia-control/
*https://endmyopia.org/myopia-madness-glasses-way-strong/
*https://endmyopia.org/retail-optometry-even-science/
*https://endmyopia.org/eye-uses-chromatic-aberration-to-guide-axial-change/
*https://endmyopia.org/american-journal-of-optometry-adult-reduction-in-axial-length/
*https://endmyopia.org/studies-does-undercorrection-cause-more-myopia/
*https://endmyopia.org/science-confirms-human-eye-axial-length-change-lens-use/
*https://endmyopia.org/another-study-glasses-cause-rapid-myopia-progression-in-children/
*https://endmyopia.org/active-focus-does-it-actually-work-clinical-science/
*https://endmyopia.org/refractive-error-myopia-concept/
*https://endmyopia.org/shocking-news-not-all-ophthalmologists-are-retarded/
*https://endmyopia.org/optics-diopters-all-the-nerdy-maths/
*https://endmyopia.org/astigmatism-part-of-natural-focus-understanding-the-brains-autofocus-mechanism/
*https://endmyopia.org/can-this-tiny-piece-of-paper-replace-your-optometrist/
*https://endmyopia.org/why-is-my-eyesight-worse-in-low-light-indoors-dusk-night-time/
*https://endmyopia.org/study-outdoor-activity-reduces-myopia-onset-in-children/
*https://endmyopia.org/study-failure-to-discuss-myopia-control-verging-on-negligent/
*https://endmyopia.org/why-you-are-nearsighted-an-animation/
===From the forum===
 
Here are papers people have mentioned on the forum:
 
* [https://www.visionsofjoy.org/pdfs/OrfieldSeeingSpace.pdf Seeing Space: Undergoing Brain Reprogramming to Reduce Myopia] by Antonia Marie Orfield (1994); [https://www.legacy.com/us/obituaries/bostonglobe/name/antonia-orfield-obituary?id=24225499 Author's obituary]
 
*[https://community.endmyopia.org/t/showdown-experiment-will-enough-outdoor-vision-shorten-my-eyes/6423/200 a paper which tries to model how the human (and generally mammalian) eyes focus on objects (animal study)] [https://www.sciencemag.org/news/2011/10/deciphering-brains-autofocus-mechanism (short article)], [https://www.pnas.org/content/108/40/16849 (full paper)]
*[https://community.endmyopia.org/t/been-to-the-opto-but-with-unexpecting-results-glaucoma/5203/5 a proto-endmyopia thing] [https://the-eye.eu/public/concen.org/Five_Health_Classics/BENJAMIN%2C%20Harry%20-%20Better%20Sight%20Without%20Glasses%20%281962%29.pdf (here is the direct link to an old book, start with page 102.)]
*[https://community.endmyopia.org/t/been-to-the-opto-but-with-unexpecting-results-glaucoma/5203/19 If you have glaucoma, try vitamin b3] (Clin & Exp Ophtalm. Sept. 2020, doi: 10.1111/ceo.13818)
*[https://community.endmyopia.org/t/my-journey-from-4-25-halmadavid/5080/245 Probability of myopia in children with high refined carbohydrates consumption in France] [https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01602-x (direct link to research article)]
*[https://community.endmyopia.org/t/doubts-about-the-need-for-outdoors-and-avoiding-screen-time/8940/18 on the effects of outdoor light on myopia progression] [https://www.nature.com/articles/519276a (direct link to article)]
* [http://www.myopia.org/bifocals.htm Bifocal Control of Myopia study by Oakley and Young, 1975.]
*[https://community.endmyopia.org/uploads/short-url/2WB7z5dmF3Rk7tdwlslsf9zcwh0.pdf Visual Conditions of Symphony Musicians]
 
* a bunch  at [https://community.endmyopia.org/t/better-than-eye-chart/15290/11 Better than eye chart?] [https://www.dyop.info/documents/Measuring_Visual_Cylinder_and_Axis_with_a_Dyop.pdf (pdf)], [https://www.bitchute.com/video/yPeGRG4qWQsi/ (visual acuity testing demo)], [https://www.dyop.info/documents/How_We_See.pdf (how we see pdf)], [https://www.dyop.info/documents/Snellen_vs_Dyop-Cataracts_Gordon.pdf (pdf)], [https://www.dyop.info/documents/Snellen_vs_Dyop_Refractions-Sanni.pdf (pdf)], [https://www.dyop.info/documents/Dyslexia_and_Color_Perception-SandraStark.pdf (pdf)], [https://www.dyop.info/documents/Which_Optotype_Are_You_Using.pdf (pdf)], etc.  Discussion is about a proprietary tool that works better than the Snellen chart.
*  [https://www.ncbi.nlm.nih.gov/books/NBK580526/#!po=11.1765 Pigment Dispersion Syndrome]


===From Discord or the wiki===
* [https://ia803109.us.archive.org/32/items/BETTERSIGHTWITHOUTGLASSESHarryBenjamin/BETTER%20SIGHT%20WITHOUT%20GLASSES%20harry%20benjamin.pdf Better sight without glasses by Dr. Harry Benjamin] (pdf) (related to [[Bates Method]], first published 1929)
[[Category:Articles]]
[[Category:Articles]]
* a [https://github.com/kevindirect/papers-medbio/tree/master/conditions/opthamology/vision/myopia/papers collection of papers] on accommodation, defocus, lifestyle, miscellaneous, and myopia
==Documented case registry (EndMyopia)==
EndMyopia maintains a public, openly-licensed registry of adult myopia-reduction cases, deposited as a citable dataset and analysed in a preprint:
*Steiner, J. (2026). ''EndMyopia case registry: 273 adult cases'' [Dataset]. Zenodo. [https://doi.org/10.5281/zenodo.21016340 doi:10.5281/zenodo.21016340] (CC-BY-4.0)
*Steiner, J. (2026). ''A self-reported registry of adult myopia reduction: 273 documented cases (2013–2026)'' [Preprint]. Zenodo. [https://doi.org/10.5281/zenodo.21230819 doi:10.5281/zenodo.21230819]
The dataset is machine-readable and source-linked; median recorded reduction was −2.00 D, with 42 of 273 cases carrying third-party-exam or official-record corroboration. The data are self-reported and not a clinical trial.